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  Indian J Med Microbiol
 

Figure 4: An overview of the mechanism that results in the symptoms of Samter's triad. A decrease in the activity of the cyclooxygenase pathway results in increased arachidonic acid metabolism by the 5-lipoxygenase system. The resultant increase cysteinyl leukotrienes and interleukin -4 lead to the characteristic manifestations of Samter's triad. COX = cyclooxygenase; 5-lipoxygenase; Cys-LT = cysteinyl leukotrienes; IL-4 = interleukin 4

Figure 4: An overview of the mechanism that results in the symptoms of Samter's triad. A decrease in the activity of the cyclooxygenase pathway results in increased arachidonic acid metabolism by the 5-lipoxygenase system. The resultant increase cysteinyl leukotrienes and interleukin -4 lead to the characteristic manifestations of Samter's triad. COX = cyclooxygenase; 5-lipoxygenase; Cys-LT = cysteinyl leukotrienes; IL-4 = interleukin 4