Oman Journal of Ophthalmology

ORIGINAL ARTICLE
Year
: 2009  |  Volume : 2  |  Issue : 1  |  Page : 33--38

Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results


Maria Clara Arbelaez, Maria Bernardita Sekito, Camila Vidal, Sanak Roy Choudhury 
 Muscat Eye Laser Center, Muscat, Oman

Correspondence Address:
Maria Clara Arbelaez
Muscat Eye Laser Center, P.O. Box 938 PC 117 Muscat
Oman

Background: The aim of this study is to evaluate the safety and effectiveness of riboflavin-ultraviolet type A (UV-A) light rays induced cross-linking of corneal collagen in improving visual acuity and in stabilizing the progression of keratoconic eyes. The method of corneal cross-linking using riboflavin and UV-A light is technically simple and less invasive than all other therapies proposed for keratoconus. It is the only treatment that treats not only the refractive effects of the condition but the underlying pathophysiology. Materials and Methods: In this prospective, nonrandomized clinical study, 20 eyes of 19 patients with keratoconus were treated by combined riboflavin UV-A collagen cross linking. The eyes were saturated with riboflavin solution and were subjected for 30 min under UV-A light with a dose parameter of 3 mW/cm 2 . Safety and effectiveness of the treatment was assessed by measuring the uncorrected visual acuity, best corrected visual acuity, manifest cylinder/sphere, keratometry, pachymetry, posterior and anterior elevations from Pentacam and corneal aberrations at 6 months and 1 year post-treatment. Results: Comparative analysis of the pre-operative and 1 year post-operative evaluation showed a mean gain of 4.15 lines of UCVA ( P = 0.001) and 1.65 lines of BCVA ( P = 0.002). The reduction in the average keratometry reading was 1.36 D ( P = 0.0004) and 1.4 D ( P = 0.001) at the apex. Manifest refraction sphere showed a mean reduction of 1.26 D ( P = 0.033) and 1.25 D (0.0003) for manifest cylinder. Topo-aberrometric analysis showed improvement in corneal symmetry. Conclusion: Cross-linking was safe and an effective therapeutical option for progressive keratoconus.


How to cite this article:
Arbelaez MC, Sekito MB, Vidal C, Choudhury SR. Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results.Oman J Ophthalmol 2009;2:33-38


How to cite this URL:
Arbelaez MC, Sekito MB, Vidal C, Choudhury SR. Collagen cross-linking with riboflavin and ultraviolet-A light in keratoconus: One-year results. Oman J Ophthalmol [serial online] 2009 [cited 2021 May 14 ];2:33-38
Available from: https://www.ojoonline.org/article.asp?issn=0974-620X;year=2009;volume=2;issue=1;spage=33;epage=38;aulast=Arbelaez;type=0