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Year : 2021  |  Volume : 14  |  Issue : 2  |  Page : 108-111

Cancer-associated retinopathy 4 years after surgery for ovarian cancer

1 Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece
2 Department of Ophthalmology, phthalmiatrion Athinon, Athens, Greece
3 Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

Correspondence Address:
Prof. Irini Chatziralli
Assistant Professor Irini Chatziralli, 2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Attikon Hospital, 1 Rimini street, Haidari, 12462
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ojo.ojo_352_20

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A 71-year-old woman presented with progressive, bilateral, blurred vision and nyctalopia for the last 6 months. Her past medical history included total hysterectomy and chemotherapy for ovarian cancer 4 years ago, without metastases. Optical coherence tomography revealed outer retinal layers' thinning bilaterally, while diffuse retinal pigment epithelium abnormalities were found in fundus autofluorescence. Full-field electroretinogram showed abnormalities in both a- and b-waves with significant reduction of retinal sensitivity, affecting however more the rod system. The patient was positive for alpha-enolase and was diagnosed with cancer-associated retinopathy (CAR), which developed 4-year primary cancer. Computerized tomography scan revealed an enlarged para-aortic lymph node at the left kidney, and the patient was started on chemotherapy, combined with immunosuppressive treatment. In conclusion, CAR should be suspected in patients experiencing unexplained visual disturbances, especially in the context of previous cancer.

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