Long term effect of panretinal photocoagulation on retinal nerve fiber layer parameters in patients with proliferative diabetic retinopathy

Meenakshi Wadhwani; Shweta Bali; Shibal Bhartiya; Manish Mahabir; Ashish Upadhaya; Tanuj Dada; Anu Sharma; Sanjay Kumar Mishra

doi:10.4103/ojo.OJO_39_2018

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ORIGINAL ARTICLE

Year : 2019 | Volume : 12 | Issue : 3 | Page : 181-185

Long term effect of panretinal photocoagulation on retinal nerve fiber layer parameters in patients with proliferative diabetic retinopathy

Meenakshi Wadhwani¹, Shweta Bali², Shibal Bhartiya³, Manish Mahabir⁴, Ashish Upadhaya⁵, Tanuj Dada⁶, Anu Sharma⁷, Sanjay Kumar Mishra⁸
¹ Department of Community Ophthalmology, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India
² Department of Ophthalmology, University of Otawa, Canada
³ Glaucoma Unit, Fortis Hospital, Gurugram, Haryana, India
⁴ Retina Unit, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India
⁵ Department of Biostatics, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India
⁶ Glaucoma Unit, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India
⁷ Retina Lab, Dr. Rajendra Prasad Centre For Ophthalmic Sciences, AIIMS, New Delhi, India
⁸ Department of Ophthalmology, Command Hospital (Central Command), Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Sanjay Kumar Mishra
Department of Ophthalmology, Command Hospital (Central Command), Lucknow - 226 002, Uttar Pradesh
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ojo.OJO_39_2018

PURPOSE: This study aimed to evaluate the long-term effect of panretinal photocoagulation (PRP) on the retinal nerve fiber layer (RNFL) in patients with proliferative diabetic retinopathy (PDR). METHODS: This was a prospective longitudinal cohort study examining 42 eyes of 42 patients with PDR undergoing PRP. Peripapillary RNFL thickness (RNFLT) was measured using spectral-domain optical coherence tomography at baseline, 1 year, and 3 years following PRP. RESULTS: The mean “average RNFLT” was 89.88 ± 14.26 μm at baseline, 85.75 ± 11.36 μm at 1-year follow-up, and 83.33 ± 11.96 μm at 3-year follow-up. There was a statistically significant difference in the average RNFL thickness at baseline and 1 year and 3 years after PRP. At 1-year follow-up, superior, inferior, and nasal RNFL measurements reduced significantly from baseline (P < 0.01). The reduction in RNFL remained statistically significant for superior and inferior quadrants 3 years after PRP. CONCLUSION: PRP causes a reduction in RNFL thickness until 3 years after the procedure. Caution should be exercised while interpreting peripapillary RNFL thickness scans in patients who have undergone PRP for diabetic retinopathy.

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