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CASE REPORT
Year : 2012  |  Volume : 5  |  Issue : 3  |  Page : 184-186

Intravitreal ranibizumab as salvage therapy in an extremely low-birth-weight infant with rush type retinopathy of prematurity


1 Department of Ophthalmology, Changhua Christian Hospital, Changhua; School of Medicine, Chung Shan Medical University, Taichung; Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan
2 Department of Ophthalmology, Changhua Christian Hospital, Changhua; School of Medicine, Chung Shan Medical University, Taichung, Taiwan

Correspondence Address:
Chun-Ju Lin
Department of Ophthalmology, 135 Nanxiao St., Changhua County 500
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-620X.106103

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We report the effects of intravitreal ranibizumab as salvage therapy in an extremely low-birth-weight (ELBW) infant with rush type retinopathy of prematurity (ROP). This case was a girl of 23 weeks gestational age weighing 480 g at birth. At a postconceptual age of 33 weeks, she presented with zone 1, stage 3 ROP with plus disease. Despite intravitreal bevazucimab and laser photocoagulation, extraretinal fibrovascular proliferation persisted. Intravitreal 0.25 mg (0.025 ml) ranibizumab was injected OU. After treatment, extraretinal fibrovascular proliferation disappeared. Fundus examination showed flat retinas and normal vasculature in both eyes. She has been followed up for 2 years. Intravitreal ranibizumab injection seems effective and well tolerated as salvage therapy in an ELBW infant with rush type ROP. No short-term ocular or systemic side effects were identified. More cases and longer follow-up are mandatory.


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