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Year : 2009  |  Volume : 2  |  Issue : 2  |  Page : 94-95 Table of Contents   

Rebound effect following intravitreal bevacizumab in branch retinal vein occlusion

Vitreoretina Service, Sri Sankaradeva Nethralaya, Guwahati, India

Date of Web Publication30-Jun-2009

Correspondence Address:
Satyen Deka
Sri Sankaradeva Nethralaya, Beltola, Guwahati - 781 028, Assam
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-620X.53042

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How to cite this article:
Deka S, Kalita K, Singh SK. Rebound effect following intravitreal bevacizumab in branch retinal vein occlusion. Oman J Ophthalmol 2009;2:94-5

How to cite this URL:
Deka S, Kalita K, Singh SK. Rebound effect following intravitreal bevacizumab in branch retinal vein occlusion. Oman J Ophthalmol [serial online] 2009 [cited 2023 Mar 31];2:94-5. Available from: https://www.ojoonline.org/text.asp?2009/2/2/94/53042

Bevacizumab (Avastin, Genentech Inc., San Francisco, CA) is a 149 kD humanized monoclonal antibody directed against all isoforms of vascular endothelial growth factor A (VEGF-A), approved by the US Food and Drug Administration (FDA) in February 2004, for intravenous use in metastatic colorectal cancer. Off-label intravitreal injections of bevacizumab (Avastin) have been given for the treatment of various neovascular and exudative ocular diseases since May 2005. [1],[2] We report rebound effect following intravitreal bevacizumab injection in branch retinal vein occlusion (BRVO).

A 50-year-old man, presented with a two weeks' history of blurred vision in his left eye. He gave past history (before five years) of vitreous hemorrhage in his right eye for which vitrectomy was advised, but not done. Past medical history was remarkable for hypertension, dyslipidemia, and eczema. His best-corrected visual acuity (BCVA) in the right eye was hand movement close to the face and, 20/30 N8 in the left eye.

Slit lamp examination of the anterior segment was unremarkable and both eyes had normal intraocular pressure. Four mirror gonioscopy was normal in both eyes with 360 degrees open angle. The right fundus was not visible and examination of left fundus showed superotemporal BRVO with macular edema [Figure 1]A. Fundus fluorescein angiography (FFA) of the left eye [Figure 1]B confirmed the diagnosis of BRVO. Optical coherent tomography showed macular edema [Figure 1]C. After discussing treatment options and obtaining informed consent, an off-label intravitreal injection of bevacizumab 1.25 mg in 0.05 ml was administered in his left eye. After one-month treatment with bevacizumab injections, his left eye vision improved to 20/20 N6 with significant resolution of BRVO and macular edema. The follow-up after two months revealed visual acuity of 20/20 N6 with further resolution of BRVO and macular edema [Figure 2]. One month later he reported again with sudden blurring of vision in the left eye of three days duration. On examination BCVA in his left eye was 20/30 N8 and there was rebound appearance of BRVO [Figure 3]A; FFA corroborated the clinical findings [Figure 3]B.

Laser photocoagulation and systemic steroid has been traditionally used for patients with BRVO. The tissue damage from laser and its disappointing visual restoration led to the development of anti-VEGF therapies. Bevacizumab is an alternate treatment option for BRVO, which offers significant advantages over steroid and laser treatment. It can be instituted without delay unlike laser which necessitates clearing of retinal hemorrhages. Using intravitreal bevacizumab, a positive biologic effect has been observed with significant resolution of BRVO and macular edema. [3],[4] Literature suggests that the cumulative probability of developing a second episode of the same or a different type of retinal vein occlusion in the same eye was 0.9% within two years and 2.5% within four years. [5] Our case showed rebound effect following intravitreal bevacizumab injection and a recurrence of BRVO involving the same arteriovenous crossing site after three months. We hypothesize that intravitreal bevacizumab gives temporary benefit in BRVO and attribute the rebound effect to falling drug levels.

   References Top

1.Rosenfeld PJ, Moshfeghi AA, Puliafito CA. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Laser Imaging 2005;222:331-5.  Back to cited text no. 1    
2.Iturralde D, Spaide RF, Meyerle CB, Klancik JM, Yannuzzi LA, Fisher YL, et al. Intravitreal bevacizumab (Avastin) treatment of macular edema in central retinal vein occlusion; a short-term study. Retina 2006;26:279-84.  Back to cited text no. 2    
3.Melvin DR, Dante JP, Alessandro AC, Ma'an AN, Robert LA. Intravitreal bevacizumab (Avastin) in the treatment of macular edema secondary to branch retinal vein occlusion. Retina 2007;27:419-25.  Back to cited text no. 3    
4.Matsumoto Y, Bailey KF, Enrico P, Michael JC, Daniela C, Ferrara AC, Yannuzzi LA. Rebound macular edema following bevacizumab (Avastin) therapy for retinal venous occlusive disease. Retina 2007;27:426-31.  Back to cited text no. 4    
5.Hayreh SS. Current Ophthalmology: Retinal vein occlusion. Indian J Ophthalmol 1994;42:109-32.  Back to cited text no. 5  [PUBMED]  Medknow Journal


  [Figure 1], [Figure 2], [Figure 3]

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