Oman Journal of Ophthalmology

: 2018  |  Volume : 11  |  Issue : 2  |  Page : 164--165

Intravitreal gas injection with prone positioning for giant retinal pigment epithelial tear

Deependra Vikram Singh1, Raja Rami Reddy2, Gaurav Mathur1, Yog Raj Sharma3,  
1 Retina Services, Eye-Q Institute of Retina, New Delhi, India
2 Retina Services, Neoretina Eyecare Institute, Hyderabad, Telangana, India
3 Dr. R. P. Center for Ophthalmic Sciences, All Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Deependra Vikram Singh
Eye-Q Institute of Retina, Shalimar Bagh, New Delhi - 110 088


We report a 78 year old male with acute RPE tear with sudden vision loss, who underwent intravitreal C3F8 injection for reattaching the RPE. The impact of gas on detached RPE was studied by serial OCTs and Fundus pictures.

How to cite this article:
Singh DV, Reddy RR, Mathur G, Sharma YR. Intravitreal gas injection with prone positioning for giant retinal pigment epithelial tear.Oman J Ophthalmol 2018;11:164-165

How to cite this URL:
Singh DV, Reddy RR, Mathur G, Sharma YR. Intravitreal gas injection with prone positioning for giant retinal pigment epithelial tear. Oman J Ophthalmol [serial online] 2018 [cited 2020 Jul 12 ];11:164-165
Available from:

Full Text


Giant retinal pigment epithelium (RPE) tear has been associated with profound vision loss. RPE tear has been found to develop spontaneously, following laser, photodynamic therapy, and intravitreal injections.[1],[2],[3],[4] Incidence of RPE tear has been reported to be variable from 1.6% to 12%.[1],[3] Natural course of giant RPE tear is not favorable and vision loss from loss of photoreceptors unsupported by RPE is inevitable.[3] Very few interventions for giant RPE tear have been reported.[5] We report a 78-year-old male with acute RPE tear with sudden vision loss, who underwent intravitreal C3F8 injection. The impact of intravitreal gas on detached RPE was studied by serial optical coherence tomographies (OCTs) and fundus pictures.

 Case Report

A 78-year-old male patient presented with sudden painless vision loss OS for the last 3 days. His best-corrected visual acuity (BCVA) was 20/400 OD and 20/80 in OS. Anterior segment examination was unremarkable OU. Fundus examination revealed large disciform scar OD and giant RPE tear with subretinal hemorrhage OS [Figure 1]a and [Figure 1]b. RPE tear was >6 DD extending across the posterior pole. Imaging with Heidelberg Spectralis OCT (Heidelberg Engineering, Heidelberg Germany) for OS confirmed a large RPE tear with detached RPE along with serous retinal detachment (RD) [Figure 2]. Very minimal folding and wrinkling of RPE were also noted. Prognosis and treatment options were discussed with the patient in detail. Intravitreal C3F8 injection with prone positioning was advised. With informed consent, patient underwent intravitreal C3F8 injection in OS. The patient maintained prone position for 2 weeks. The patient was followed up weekly with Fundus pictures and OCT scans to analyze the impact of intravitreal gas and prone positioning on RPE tear and associated serous RD [Figure 1]c and [Figure 1]d. At 2 weeks follow-up, comparison of OCT scans revealed reduced height and extent of serous RD, but no change in the position of detached RPE and BCVA was reduced to 20/120 OS. The patient received monthly 3 bevacizumab injections at 4-week intervals. His final BCVA in OS remained stable at 20/120 at 4 months follow-up. We fail to demonstrate any impact of intravitreal C3F8 gas injection with prone positioning on fresh giant RPE tear associated with age-related macular degeneration.{Figure 1}{Figure 2}


While pneumatic displacement of subretinal and sub-RPE blood has been well described, very few interventions for RPE tear have been described in literature. Factors affecting displacement of subretinal blood were analyzed by Stopa et al. who pointed out role of gravitation force on displacement.[5] Intravitreal gas injection with prone positioning displaces the blood in subretinal space and changes its natural course. Hence, authors hypothesized that intravitreal gas bubble along with prone positioning might impact a fresh giant RPE tear also and the same was attempted for this patient. However, we failed to demonstrate any impact of intravitreal gas injection with prone positioning on RPE tear. Although a single case may not be sufficient to conclude the ineffectiveness of this technique, the failure does provide insight into the mechanisms involved in RPE tear and also calls for more, possibly surgical, interventions for this visually devastating complication.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.


1Garg S, Brod R, Kim D, Lane RG, Maguire J, Fischer D. Retinal pigment epithelial tears after intravitreal bevacizumab injection for exudative age-related macular degeneration. Clin Exp Ophthalmol 2008;36:252-6.
2Gutfleisch M, Heimes B, Schumacher M, Dietzel M, Lommatzsch A, Bird A, et al. Long-term visual outcome of pigment epithelial tears in association with anti-VEGF therapy of pigment epithelial detachment in AMD. Eye (Lond) 2011;25:1181-6.
3Doguizi S, Ozdek S. Pigment epithelial tears associated with anti-VEGF therapy: Incidence, long-term visual outcome, and relationship with pigment epithelial detachment in age-related macular degeneration. Retina 2014;34:1156-62.
4Desai UR, Kumar N. Surgical treatment of an exudative retinal detachment associated with a giant retinal pigment epithelial tear. Ophthalmic Surg Lasers Imaging Retina 2013;44:97-9.
5Stopa M, Lincoff A, Lincoff H. Analysis of forces acting upon submacular hemorrhage in pneumatic displacement. Retina 2007;27:370-4.