Oman Journal of Ophthalmology

: 2014  |  Volume : 7  |  Issue : 2  |  Page : 78--80

Long-term results of intravitreal ranibizumab for osteoma-related choroidal neovascularization in a child

Aditi Gupta1, Lingam Gopal2, Parveen Sen1, Dhanashree Ratra1, Chetan Rao1,  
1 Department of Vitreoretinal Services, Shri Bhagwan Mahavir, 18, College Road, Sankara Nethralaya, Chennai, Tamil Nadu, India
2 Department of Ophthalmology, National University Hospital, 5 Lower Kent Ridge Road, Singapore

Correspondence Address:
Aditi Gupta
Vitreo-Retina Fellow, Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, College Road, Chennai - 600 006, Tamil Nadu


Though choroidal osteoma is a rare benign tumor, associated choroidal neovascularization (CNV) can be a cause of severe visual loss. A nine-year-old boy presented with one-month history of decreased vision in left eye. Upon a complete ophthalmologic examination, including fundus fluorescein angiography and optical coherence tomography, he was diagnosed with choroidal osteoma-related subfoveal CNV in the left eye. The CNV was associated with subretinal hemorrhage, subretinal fluid, and cystoid macular edema. Owing to the young age and subfoveal localization of the CNV, intravitreal ranibizumab injection was performed on this patient after a detailed discussion with the parents of its safety profile. No local or systemic complications were noted. No recurrence of CNV lesion was noted during 30 months of follow-up, and the vision was maintained. This report shows the favorable outcome of intravitreal injection of ranibizumab in choroidal osteoma-related CNV in a child.

How to cite this article:
Gupta A, Gopal L, Sen P, Ratra D, Rao C. Long-term results of intravitreal ranibizumab for osteoma-related choroidal neovascularization in a child.Oman J Ophthalmol 2014;7:78-80

How to cite this URL:
Gupta A, Gopal L, Sen P, Ratra D, Rao C. Long-term results of intravitreal ranibizumab for osteoma-related choroidal neovascularization in a child. Oman J Ophthalmol [serial online] 2014 [cited 2020 Sep 19 ];7:78-80
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Full Text


Choroidal osteoma is a rare benign tumor typically occurring in young females; however, males and children less than age ten have been diagnosed as having a choroidal osteoma. [1] Development of choroidal neovascularization (CNV) may lead to severe visual loss. [1] Recently, intravitreal ranibizumab injection has been used with success in the treatment of the CNV associated with choroidal osteoma in adults [2] as well as children. [3] Also, there are recent reports of favorable outcome of ranibizumab injection in children for CNV secondary to varied etiologies. [4],[5] Herein, we report the results of ranibizumab for treating osteoma-related CNV in a child. We also describe the future course of the lesion over a follow-up of 30 months.

 Case Report

A nine-year-old boy presented with the complaint of decreased vision in left eye since one month. There was no significant medical or family history. On examination, best corrected visual acuity (BCVA) was 20/20 in the right eye and 20/400 in the left eye. Anterior segment examination of both eyes and fundus examination of the right eye was unremarkable. Fundus examination of the left eye showed a slightly elevated yellowish lesion on the posterior pole [Figure 1]a. Fresh subretinal hemorrhages were noted in the center of the lesion. The B-scan ultrasound showed a subretinal lesion with high surface reflectivity, persisting at low gain with orbital shadowing behind, suggestive of choroidal osteoma [Figure 1]b. Fundus fluorescein angiography (FFA) in the left eye showed early patchy hyperfluorescence [Figure 1]c with late staining of the choroidal osteoma [Figure 1]d. In the center of the osteoma, early lacy hyperfluorescence [Figure 1]c leaking in the late phase [Figure 1]c was noted, indicative of classic CNV. There were also areas of blocked fluorescence corresponding to the subretinal hemorrhages seen clinically. Optical coherence tomography (OCT) confirmed a subfoveal CNV complex with gross CME overlying the CNV with subretinal fluid extending to the fovea [Figure 1]e. A diagnosis of left eye choroidal osteoma with CNV was made. After a detailed discussion with the parents regarding the risks and the safety profile of intravitreal ranibizumab in children, the patient received intravitreal ranibizumab (Lucentis- Novartis) injection (0.5 mg in 0.05 ml) in the left eye. Since the patient belonged to another country, monthly follow-up could not be maintained. After three months, the CNV appeared regressed with resolution of subretinal hemorrhage clinically [Figure 2]a, staining of scar with no leakage on FFA [Figure 2]b, and disappearance of fluid on OCT [Figure 2]c. CME showed only partial resolution as confirmed on OCT and FFA.{Figure 1}{Figure 2}

In view of persistent CME, despite the scarring CNV, two more injections of ranibizumab were administered at three monthly intervals. Since the cystic spaces were still persistent after third injection and CNV appeared completely scarred on OCT, it was decided to observe and defer any further injections. As noted over further follow-ups, the CNV remained inactive without any recurrence [Figure 2]d and e. However, complete regression of cystic spaces was still not achieved [Figure 2]f]. The visual acuity of left eye was maintained at 20/400. The last examination of the patient, done at 30 months by a local eye specialist, showed a stable picture with disciform scar [Figure 2]g and h and persistent, though reduced, overlying CME [Figure 2]i. The report of the last visit was sent to us by the local specialist.


We document a rare case of choroidal osteoma-related CNV in a child, treated by the use of intravitreal ranibizumab injection without local or systemic adverse effects. CNV is the most frequent cause of visual loss in choroidal osteoma, with more than half of patients expected to develop CNV. [1] Laser photocoagulation has limited efficacy in the treatment owing to lack of pigment in the tumor and atrophy of overlying retinal pigment epithelium [1] and was tried in children with limited success. [6] The results of surgical removal have also been associated with poor visual results. [7] Recently, anti-vascular endothelial growth factor (anti-VEGF) agents have been used with success in osteoma-related CNV in adults [2] and children. [3]

Kubota-Taniai M et al. recently reported successful treatment of CNV associated with choroidal osteoma with two intravitreal injections of bevacizumab in a 12-year-old girl and no recurrence till a follow-up of four years. [8] In pediatric population, as reported by Avery et al., [9] use of ranibizumab instead of bevacizumab may lower systemic exposure given its much shorter serum half-life and as found in several animal studies. There is a recent report of intravitreal ranibizumab use in an 11-year child for CNV associated with choroidal osteoma. [3] The follow-up period was two years.

In the present case, regression of CNV was noted after the first intravitreal injection of ranibizumab. However, the CME was persistent overlying the scarred membrane despite two more injections and till a follow-up of 30 months. Persistent CME overlying scarred CNV can be explained by the presence of thinned degenerated retinal pigment epithelium overlying the choroidal osteoma. [1] Such finding of persistent cystic cavities on OCT in eyes with disciform scars (secondary to wet age related macular degeneration treated with PDT) was also reported previously by Salinas-Alamán et al. [10] They suggested that in cases where intraretinal fluid is seen on OCT and no leakage is seen on FFA (called as false positives), a disciform scar should be ruled out in the fundus examination, because in these cases, no treatment is indicated. We also noted a similar course in our case. The patient maintained his vision over entire follow-up, and there was no recurrence of CNV despite persistent cystic maculopathy.

In conclusion, intravitreal ranibizumab was effective for CNV associated with choroidal osteoma in our patient.


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