About OJO | Search | Ahead of print | Current Issue | Archives | Author Instructions | Reviewer Guidelines | Online submissionLogin 
Oman Journal of Ophthalmology Oman Journal of Ophthalmology
  Editorial Board | Subscribe | Advertise | Contact
https://www.omanophthalmicsociety.org/ Users Online: 646  Wide layoutNarrow layoutFull screen layout Home Print this page  Email this page Small font size Default font size Increase font size


 
 Table of Contents    
CASE REPORT
Year : 2015  |  Volume : 8  |  Issue : 2  |  Page : 122-124  

Spontaneous ophthalmic artery occlusion in children due to Hyperhomocysteinemia


1 Department of Pediatric Ophthalmology, Strabismus and Neuro-ophthalmology, Nimmagada Prasad Children's Eye Care Centre, GMRV Campus, Visakhapatnam, Andhra Pradesh, India
2 Department of Retina and Vitreous Surgery, LV Prasad Eye Institute, GMRV Campus, Visakhapatnam, Andhra Pradesh, India
3 Department of Pediatric Ophthalmology, Strabismus and Neurophthalmology, Jasti V Ramanamma Children's Eye Care Centre, LVPEI, KAR Campus, Hyderabad, Andhra Pradesh, India

Date of Web Publication24-Jun-2015

Correspondence Address:
Dr. Virender Sachdeva
Department of Pediatric Ophthalmology, Strabismus and Neuro-ophthalmology, Nimmagada Prasad Children's Eye Care Centre, LV Prasad Eye Institute, GMRV Campus, Visakhapatnam, Andhra Pradesh - 500 034
India
Login to access the Email id

Source of Support: The work was supported by Hyderabad Eye Research Foundation (HERF), Conflict of Interest: None


DOI: 10.4103/0974-620X.159270

Rights and Permissions
   Abstract 

Ophthalmic artery occlusion usually presents as a sudden onset profound decrease in vision in the middle-aged and elderly patients following periocular procedures (retrobulbar injection/glabellar fat injection), embolism from the heart or after prolonged systemic surgery. In this report, we describe three children with spontaneous ophthalmic artery occlusion who presented with unilateral loss of vision and diagnosed elsewhere as optic atrophy whose detailed history and examination were suggestive of ophthalmic artery occlusion. Detailed systemic and laboratory evaluation revealed hyperhomocysteinemia as the only potential risk factor. To the best of our knowledge, this is the first report of the association of hyperhomocysteinemia and spontaneous ophthalmic artery occlusion.

Keywords: Children, hyperhomocysteinemia, ophthalmic artery occlusion


How to cite this article:
Sachdeva V, Garg R, Pathengay A, Kekunnaya R. Spontaneous ophthalmic artery occlusion in children due to Hyperhomocysteinemia. Oman J Ophthalmol 2015;8:122-4

How to cite this URL:
Sachdeva V, Garg R, Pathengay A, Kekunnaya R. Spontaneous ophthalmic artery occlusion in children due to Hyperhomocysteinemia. Oman J Ophthalmol [serial online] 2015 [cited 2019 Aug 26];8:122-4. Available from: http://www.ojoonline.org/text.asp?2015/8/2/122/159270


   Introduction Top


Ophthalmic artery occlusion is a rare, but blinding condition that accounts for about 2% of all the ocular vascular occlusions. [1] It usually affects the middle aged and elderly with cardiovascular disease, [1] however, rarely it has rarely been reported to affect the children and young adults (<50 years) secondary to retrobulbar corticosteroid injections, [2] intranasal corticosteroid injections, [3] autologous fat injections into the glabellar regions, [4] following embolism from the a left atrial myxoma [5] and as a complication of prolonged surgery under general anesthesia especially neuro/spinal surgery. [6] In a previous report, Ganesh et al. described spontaneous ophthalmic artery occlusion in a 7-year-old girl without any underlying etiology. [7] Hyperhomocysteinemia is reported as an independent risk factor for systemic and ocular vaso-occlusive disorders, including non arteritic ischemic optic neuropathy (NAION), central retinal artery occlusion (CRAO), and central retinal vein occlusion, isolated ischemic cranial nerve palsies, especially in young patients. [8] In this report, we describe three children with ophthalmic artery occlusion where hyperhomocysteinemia was the only risk factor. To the best of authors' knowledge, this is the first report of this presumed association.


   Case Report Top


Between November 2008 and October 2013, we saw a total of six patients with ophthalmic artery occlusion in our institute. Of these, three were children (<16 years of age at time of onset). [Table 1] summarizes the presenting features, clinical features and laboratory results of these patients. Two patients were girls and one boy. The mean age of patients at the time of onset of a decrease in vision was 12 years (range: 8-14 years).
Table 1: Clinical and demographic features of the patients


Click here to view


Two patients presented to us with a history of unilateral decrease in vision and were diagnosed to have optic atrophy previously. In two patients, the duration of the onset of symptoms was 2 months, whereas in the third patient the diminution of vision dated back to 6 years. Anterior segment examination was normal in all patients except presence of relative afferent papillary defect in the affected eye. Detailed fundus examination in these patients showed a diffuse pallor of the optic disc with marked attenuation of arterioles and diffuse retinal pigmentary (RPE) changes, suggestive of a possible ophthalmic artery occlusion [Figure 1], from patient 1 and patient 3 as representative of all the three patients]. The other eye fundus examination was unremarkable. Magnetic resonance imaging brain (done elsewhere for the evaluation of optic atrophy) in all patients was within normal limits.
Figure 1: Color Fundus photograph (montage view) of the patient 1 (a) and patient 3 (b), showing the presence of diffuse disc pallor (asterisk), attenuated blood vessels (black arrows), diffuse retinal pigmentary changes (arrow heads) along the entire retina suggestive of left ophthalmic artery occlusion in these patients

Click here to view


All the three patients underwent investigations for any potential risk factors such as diabetes mellitus, hypertension, dyslipidemia, collagen vascular disorders, source of embolism (two-dimensional echocardiography and carotid Doppler), prothromboic disorders (bleeding time, coagulation time, protein C, protein S deficiency) and serum homocysteine levels.

The erythrocyte sedimentation rate, C-reactive protein, lipid levels, blood glucose levels, blood pressure, coagulation profile, two-dimensional echo and carotid Doppler were within normal limits.

However, all the three patients had elevated serum homocysteine levels. Mean serum homocysteine levels were 37.60 μmol/L (Range: 15.20-65.00 μmol/L, standard deviation: 25.3 μmol/L normal: 3.90-13.90 μmol/L, chemiluminescence method). All patients were further evaluated for Vitamin B 12 and folic acid levels, which were found to be normal in all except one child where serum Vitamin B 12 levels was 152 pg/ml (normal folic acid >5.38 ng/ml, Vitamin B 12 -211-911 pg/ml). This patient was evaluated by a hematologist and was found to have a dietary deficiency of Vitamin B 12 . Further genetic analysis for the mutations in homocysteine metabolism were contemplated but were not feasible due to lack of facilities.

Situation and guarded visual prognosis were explained to the parents. All the patients were treated with oral vitamin supplementation (Vitamin B 6 -250 mg, Vitamin B 12 -1500 μg and folic acid-5 mg/day) and oral antiplatelet therapy (aspirin, 75 mg/day). None of the patients developed any further episodes of ocular or systemic vaso-occlusion.


   Discussion Top


This report highlights three young children with unilateral ophthalmic artery occlusion. It can be differentiated from CRAO by widespread attenuation of arterioles, RPE stippling and absence of cherry red spot [Table 2]. Ophthalmic/retinal vascular occlusion (RVO) suggested an underlying systemic disease and recommended workup of a patient with RVO is suggested in [Table 3].
Table 2: Differentiating features between central retinal artery and ophthalmic artery occlusion


Click here to view
Table 3: Suggested work up of patients with retinal vascular occlusion


Click here to view


Hyperhomocysteinemia characterized by an elevation of serum homocysteine levels, is a potent atherosclerotic risk factor that promotes thrombus formation and increases the risk of vascular occlusion.

A 5 μmol/L elevation of homocysteine levels has been reported to increase the risk of vaso-occlusive diseases by 60% in males and 80% in females with an increased odds ratio of 1.4-1.7. [9]

It has been reported that as many as 60% of the patients with ischemic strokes and 17% of young patients with NAION may have isolated hyperhomocysteinemia as a risk factor.

Similar to the previous reports, patients in our series were also young with a mean age of 14 years (range: 12-16 years). In our series, all patients presented with ophthalmic artery occlusion without any history of surgery or other known risk factor apart from the hyperhomocysteinemia.

We have previously reported a case series of young patients with abducens nerve palsy and hyperhomocysteinemia and a case of combined cilioretinal artery obstruction and NAION in a young patient with hyperhomocysteinemia.

Hyperhomocysteinemia is a potentially modifiable risk factor. Dietary supplementation of 250 mg of Vitamin B 6 , 5 mg of folic acid and 1500 μg Vitamin B 12, daily has been shown to lower serum homocysteine levels.

Although hyperhomocysteinemia has been reported with various vaso-occlusive diseases, a causal association was not proven. However, in a recent study, Al Wadani et al. [10] reported in the age and sex matched patient with retinal vein occlusion and controls showed the presence of hyperhomocysteinemia was a risk factor for the development of RVO in Indian population. Hence, the authors' recommend investigating and treat for hyperhomocysteinemia in vaso-occlusive diseases like ophthalmic artery obstruction.

The main limitation of our series is its retrospective nature with limited size. However, this is an uncommon condition and to the best of our knowledge, this is the first reported association of hyperhomocysteinemia with spontaneous ophthalmic artery occlusion. Based on our findings we recommend estimation of serum homocysteine in the work-up of young patients with spontaneous ophthalmic artery occlusion in the absence of other risk factors.


   Acknowledgment Top


We acknowledge the support of our diagnostic and Ophthalmic Photography Department for the support towards obtaining high-quality images of the patients.

 
   References Top

1.
Brown GC, Magargal LE, Sergott R. Acute obstruction of the retinal and choroidal circulations. Ophthalmology 1986;93:1373-82.  Back to cited text no. 1
[PUBMED]    
2.
Ellis PP. Occlusion of the central retinal artery after retrobulbar corticosteroid injection. Am J Ophthalmol 1978;85:352-6.  Back to cited text no. 2
[PUBMED]    
3.
Whiteman DW, Rosen DA, Pinkerton RM. Retinal and choroidal microvascular embolism after intranasal corticosteroid injection. Am J Ophthalmol 1980;89:851-3.  Back to cited text no. 3
[PUBMED]    
4.
Dreizen NG, Framm L. Sudden unilateral visual loss after autologous fat injection into the glabellar area. Am J Ophthalmol 1989;107:85-7.  Back to cited text no. 4
    
5.
Rafuse PE, Nicolle DA, Hutnik CM, Pringle CE. Left atrial myxoma causing ophthalmic artery occlusion. Eye (Lond) 1997;11:25-9.  Back to cited text no. 5
    
6.
Kothari MT, Maiti A. Ophthalmic artery occlusion: A cause of unilateral visual loss following spine surgery. Indian J Ophthalmol 2007;55:401-2.  Back to cited text no. 6
[PUBMED]  Medknow Journal  
7.
Ganesh A, Mitra S, Koul RL, Venugopalan P. Spontaneous ophthalmic artery occlusion in a child. J Pediatr Ophthalmol Strabismus 2001;38:183-5.  Back to cited text no. 7
    
8.
Pianka P, Almog Y, Man O, Goldstein M, Sela BA, Loewenstein A. Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Ophthalmology 2000;107:1588-92.  Back to cited text no. 8
    
9.
Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.  Back to cited text no. 9
    
10.
Al Wadani F, Khandekar R, Salim G, Al Ali M, Ramzi S. Hyperhomocysteinia is a risk factor for retinal venous occlusion: A case control study. Indian J Ophthalmol 2014;62:291-4.  Back to cited text no. 10
    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]



 

Top
   
 
  Search
 
  
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
   Acknowledgment
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed1432    
    Printed19    
    Emailed0    
    PDF Downloaded144    
    Comments [Add]    

Recommend this journal