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REVIEW ARTICLE
Year : 2015  |  Volume : 8  |  Issue : 1  |  Page : 3-8

Gene therapy in keratoconus


Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Mohammad Naderan
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, South Karegar Avenue, Qazvin Square, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-620X.149854

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Keratoconus (KC) is the most common ectasia of the cornea and is a common reason for corneal transplant. Therapeutic strategies that can arrest the progression of this disease and modify the underlying pathogenesis are getting more and more popularity among scientists. Cumulating data represent strong evidence of a genetic role in the pathogenesis of KC. Different loci have been identified, and certain mutations have also been mapped for this disease. Moreover, Biophysical properties of the cornea create an appropriate candidate of this tissue for gene therapy. Immune privilege, transparency and ex vivo stability are among these properties. Recent advantage in vectors, besides the ability to modulate the corneal milieu for accepting the target gene for a longer period and fruitful translation, make a big hope for stupendous results reasonable.


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