About OJO | Search | Ahead of print | Current Issue | Archives | Author Instructions | Reviewer Guidelines | Online submissionLogin 
Oman Journal of Ophthalmology Oman Journal of Ophthalmology
  Editorial Board | Subscribe | Advertise | Contact
https://www.omanophthalmicsociety.org/ Users Online: 139  Wide layoutNarrow layoutFull screen layout Home Print this page  Email this page Small font size Default font size Increase font size


 
 Table of Contents    
CLINICAL IMAGE
Year : 2011  |  Volume : 4  |  Issue : 1  |  Page : 32-34  

Sudden onset isolated complete third nerve palsy due to pituitary apoplexy


1 Department of Neurosurgery, Zynova Hospital, L.T.M.G. Hospital, Mumbai, India
2 Department of Neurosurgery, L.T.M.G. Hospital, Mumbai, India

Date of Web Publication14-Mar-2011

Correspondence Address:
Batuk Diyora
Department of Neurosurgery, 2nd Floor, L.T.M.G. Hospital, Sion (W), Mumbai - 400 022
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-620X.77661

Rights and Permissions

How to cite this article:
Diyora B, Nayak N, Kukreja S, Kamble H. Sudden onset isolated complete third nerve palsy due to pituitary apoplexy. Oman J Ophthalmol 2011;4:32-4

How to cite this URL:
Diyora B, Nayak N, Kukreja S, Kamble H. Sudden onset isolated complete third nerve palsy due to pituitary apoplexy. Oman J Ophthalmol [serial online] 2011 [cited 2020 Feb 26];4:32-4. Available from: http://www.ojoonline.org/text.asp?2011/4/1/32/77661

Pituitary apoplexy is characterized by a sudden onset of headache, visual impairment, opthalmoplegia, altered mental status, and hormonal dysfunction. It is a medical emergency caused by acute hemorrhage or infarction of the pituitary gland / tumor. [1]

A rapid rise in intrasellar pressure causes compression of the adjacent cranial nerves resulting in cranial nerve palsy. [2] Isolated complete third nerve palsy due to pituitary apoplexy is uncommon. [3],[4],[5] We report a case of a sudden onset of isolated complete third nerve palsy as the presenting sign of pituitary apoplexy.

A 55-year-old male presented with a sudden onset of a drooping right eyelid following an episode of mild-to-moderate headache. On admission, he was conscious and well-oriented to time, place, and person. His vision was 6 / 6 in both eyes and there was a mild bilateral temporal field restriction on confrontation examination. His right pupil was 5 mm in diameter and not reacting to light, while the left pupil was 3 mm and reacting to light. He had complete ptosis on the right side. The right eye was in a down and out position [Figure 1]. His left eye movements were normal. The remaining cranial nerve functions were normal. Magnetic resonance imaging (MRI) of the brain revealed a heterogeneously enhancing pituitary tumor, which was hyperintense on T-1 weighted images and hypointense on T2-weighted images [Figure 2] and [Figure 3]. Magnetic resonance angiography (MRA) was normal. Pituitary hormones were within normal levels. The sellar mass was excised via a sublabial transphenoidal approach. The tumor tissue along with altered blood was drained out. A near complete excision of the pituitary adenoma was achieved. The histopathological examination confirmed pituitary adenoma with extensive areas of hemorrhage and necrosis, consistent with apoplexy [Figure 4]. The postoperative course was uneventful and the patient had a good clinical recovery. At the six-week follow-up, the right-sided ptosis and eye movements had completely recovered; however, pupillary dilatation was persistent [Figure 5]. A follow-up MRI of the brain showed no residual adenoma with the chiasm in normal position [Figure 6].
Figure 1: Photographs showing right side third nerve palsy. A: Primary position. B: Left gaze

Click here to view
Figure 2: MRI brain sagittal view. A: T-1 weighted imaging showing a hyperintense mass lesion occupying the sellar region. B: T-2 weighted imaging showing a hypointense lesion. C: Post gadolinium sequence showing heterogenous enhancement of the sellar lesion

Click here to view
Figure 3: Post gadolinium MRI brain in axial (A) and coronal views (B), showing the sellar mass extending into the right cavernous sinus

Click here to view
Figure 4: Microscopic features of pituitary apoplexy. Photomicrograph shows tumor cells with hemorrhage (Hematoxylin-Eosin stain). (A) x10 view (B) x 40 view

Click here to view
Figure 5: Postoperative photographs showing recovery of right-sided third nerve palsy A: Primary position, B: Left gaze

Click here to view
Figure 6: Postoperative MRI brain (sagittal view): (A) T-1 weighted and (B) T-2 weighted images showing no residual adenoma with chiasm in the normal position

Click here to view


Ophthalmic manifestations in pituitary apoplexy result from the expansion of the tumor in the lateral and / or superior direction. Multiple cranial nerve palsies (III, IV, V, VI) occur from the lateral expansion of the pituitary tumor, while superior expansion results in dysfunction of the optic nerve and optic chiasm.

The occulomotor nerve is more susceptible to laterally transmitted pressure by expanding the pituitary mass, because of its anatomical location. Slow onset third nerve palsy results from either gradual compression of the nerve in the sinus wall or direct infiltration of the nerve by the pituitary tumor. Sudden onset third nerve palsy results from hemorrhage or infarct in the pre-existing pituitary mass and is attributed to the compromising of the vascular supply of the nerve, due to compression of the vasa nervosum originating in the internal carotid artery. [6]

The most common cause of sudden onset third nerve palsy is the posterior communicating (Pcom) artery aneurysm. The differential diagnosis includes intracranial hemorrhage, subarachnoid hemorrhage, bacterial meningitis, cavernous sinus thrombosis, and midbrain infraction.

Treatment of pituitary apoplexy includes medical and surgical management. [5] Intravenous steroid is necessary to prevent acute adrenal insufficiency. The definitive treatment for pituitary apoplexy is early surgical decompression, which relieves the pressure on the sellar and suprasellar structures.

Pituitary apoplexy should be considered early in the differential diagnosis of sudden onset isolated complete third nerve palsy. Early diagnosis and prompt neurosurgical decompression can restore pituitary function and result in good clinical recovery of the third nerve function.

 
   References Top

1.Verrees M, Arafah BM, Selman WR. Pituitary tumor apoplexy; characteristics, treatments, and outcomes. Neurosurgery Focus 2004;16:1-7.  Back to cited text no. 1
    
2.Molitch ME. Gonadotroph-cell pituitary adenomas. N Engl J Med 1991;324:626-7.   Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.Rossitch E Jr, Carrazana EJ, Black PM. Isolated oculomotor nerve palsy following apoplexy of a pituitary adenoma. J Neurosurg Sci 1992;36:103-5.  Back to cited text no. 3
[PUBMED]    
4.Kashkouli M, Khalatbari M, Yahyavi S, Borghei-Razavi, Sanjari M. Pituitary Apoplexy Presenting as Acute Painful Isolated Unilateral Third Cranial Nerve Palsy. Arch Iran Med 2008;4:466-8.  Back to cited text no. 4
    
5.Cho W, Joo S, Kim T, Seo B. Pituitary Apoplexy Presenting as Isolated Third Cranial Nerve Palsy with Ptosis: Two Case Reports. J Korean Neurosurg Soc 2009;45:118-21.  Back to cited text no. 5
    
6.Cahill M, Bannigan J, Eustace P. Anatomy of the extraneural blood supply to the intracranial oculomotor nerve. Br J Ophthalmol 1996;80:177-81.  Back to cited text no. 6
[PUBMED]  [FULLTEXT]  


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]


This article has been cited by
1 Sudden headache, third nerve palsy and visual deficit: thinking outside the subarachnoid haemorrhage box
D. Ni Chroinin,J. Lambert
Age and Ageing. 2013; 42(6): 810
[Pubmed] | [DOI]



 

Top
   
 
  Search
 
  
    Similar in PUBMED
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References
    Article Figures

 Article Access Statistics
    Viewed4368    
    Printed136    
    Emailed2    
    PDF Downloaded353    
    Comments [Add]    
    Cited by others 1    

Recommend this journal