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ORIGINAL ARTICLE
Year : 2009  |  Volume : 2  |  Issue : 2  |  Page : 73-78

Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results


1 Vitreo-retina Unit, Aravind Eye Hospital, Coimbatore, India; Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Sultanate Of Oman
2 Vitreo-retina Unit, Aravind Eye Hospital, Coimbatore, India
3 Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Sultanate Of Oman

Correspondence Address:
George J Manayath
Department of Ophthalmology, Sultan Qaboos University Hospital, Post Box: 38, Al Khod, Muscat, Sultanate Of Oman-123

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-620X.53036

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Background: There is no proven effective treatment for vision loss in central retinal vein occlusion (CRVO). Bevacizumab has been reported in small series with limited follow-up, to have a positive effect in reducing cystoid macular edema (CME) and improving vision in CRVO. Purpose: To report long-term results with the use of bevacizumab in CRVO. Materials and Methods: Prospective interventional case series included 15 patients, serially evaluated with best corrected visual acuity (BCVA), optical coherence tomography (OCT), fluorescein angiography, and tonometry. Results were statistically analyzed. Results: Mean follow-up was 12 3.6 months (range, 6−18 months); mean number of injections was 2.2 (range, 1−4) per patient. Statistically significant reduction of macular thickness (P < 0.001) was seen at six weeks (mean, 346 ); three months (mean, 353 ); six months (mean, 348 ); and final follow-up (mean, 342 ). Significant BCVA improvement was seen at six weeks (mean, 0.27 logMAR), three months (mean, 0.3 logMAR), three months (0.15 logMAR), and final follow-up (mean, 0.21 logMAR) (P = 0.009). Also, 73.3% patients had BCVA improvement at the last follow-up. Conclusion: Intravitreal bevacizumab is an effective treatment option for CME in CRVO patients. Reinjections at appropriate timing, based on the OCT findings, are important for better visual outcome.


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